Sealy Center on Aging Pepper Investigator's Lecture

"Regulation of VLDL-TG Kinetics: Clinical Significance"

  1. To present the effects of gender, diet, exercise and obesity to VLDL-TG metabolism in humans
  2. To briefly describe the known biochemical mechanisms regulating VLDL-TG metabolism in humans
  3. To discuss the translational value of the findings

Presented by:
Labros Sidossis, PhD
Professor, Department of Internal Medicine-Geriatrics, Sealy Center on Aging,
Institute for Translational Sciences and Shriners Burns Institute
University of Texas Medical Branch

Wednesday, November 2, 2011
12:00 - 1:00 pm
Rebecca Sealy Hospital, Conference Room 6.100
Everyone is welcome to attend

The Institute for Translational Sciences presents:
Topics in Translational Research Workshop

The Biomarker Discovery Pipeline


  • Overview of the biomarker development pipeline
  • Biomarker discovery: Discovery proteomics
  • Predictive panel development
  • Verification and quantitation
  • Clinical laboratory (CLIA/CAP) considerations in biomarker development
  • Regulatory considerations

Wednesday, Nov. 16
Levin Hall Dining Room
3:00pm - 5:00pm

Join us for the Wine & Cheese Reception from 5:00pm - 6:00pm in the Levin Hall Foyer!

The Institute for Translational Sciences presents:
Topics in Translational Research

Update on the Metabolic Syndrome, Nicola Abate, MD

4th Annual South Regional Meeting of the
American Physician Scientist Association

Faculty, residents, medical, and MD-PhD students will gather to discuss translational research and medicine.

Date: November 5, 2011
Location: Levin Hall

Register today at
Registration is FREE for UTMB students.

Keynote Speakers:

  • Dr. Allan R. Brasier, MD, Leon Bromberg Professor of Medicine, Department of Internal Medicine, UTMB
  • Dr. Richard Sutton, MD, PhD, Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis, Yale University School of Medicine

Sponsored by:

  • UTMB MD-PhD Combined Degree Program
  • Infectious Diseases Society of America
  • UTMB Department of Anesthesiology
  • UTMB School of Medicine, Office of Student Affairs and Admissions

"Research Central" Happening

October 14, 2011
11 am to 2 pm
John Sealy Hospital Lobby Corridor

Stop by to find out about:
• Currently enrolling clinical research studies at UTMB
• ResearchMatch registry for volunteers & recruitment tool for researchers

Email: Carrie Derkowski
Institute for Translational Sciences

Nutrition Study: Volunteers Wanted

Do you or a family member have high triglycerides (an elevated blood fat level)?

We have an ongoing study that aims to determine if adding amino acids to your diet may help lower your triglycerides. The study will be conducted at the Institute for Translational Sciences Clinical Research Center (ITS-CRC) at UTMB and consists of:

  • Screening for diabetes and other diseases
  • 10 weeks of nutritional supplementation
  • Experimental trials - two i.v. catheters, infusion of tracers (small amounts of labeled fat), muscle biopsies, drinks containing amino acids (building blocks of protein), blood sampling, body composition analysis, and measurement of fat levels in liver and muscle

Volunteers must:

  • be 50 - 75 years (male or female)
  • have screening results showing elevated fat levels in blood

Volunteers cannot:

  • have diabetes
  • be currently taking medication known to alter lipid levels

Volunteers will be reimbursed for lost time, travel and expenses. If you would like to know more about this study, please contact either:

Kristi Craig: (phone: (409) 770-6619; email:
Dr. Nick Hurren: (phone: (409) 770-6954; email:

Melanoma Research Alliance Seeks Innovative Proposals

to Address Gap in Translational Science

SOURCE: Melanoma Research Alliance (MRA)

$ AVAILABLE: MRA plans to provide at least $3 million in new funding for Individual Investigator Awards during the 2011-12 cycle. Proposals will be accepted for Individual Investigator Awards in the following categories:

  • Young Investigator Awards provide investigators within four years of their first academic faculty appointment with $75,000 per year for two to three years to accomplish innovative, early concept projects.
  • Established Investigator Awards provide investigators with an established record of scientific productivity with up to $125,000 per year for two to three years to conduct projects supported by preliminary data.
  • Pilot Awards provide an award of $50,000 per year for two years for potentially transformative pilot studies from investigators who are past the initial four years of their first academic faculty appointment.
ELIGIBILITY: Please see $ AVAILABLE for eligibility information.

PURPOSE: The Melanoma Research Alliance is a public charity that supports an international cross-disciplinary group of biomedical researchers with the clinical and scientific expertise to explore, identify, and pursue innovative solutions to critical research questions leading to better treatments and a cure for melanoma patients.

The MRA is soliciting proposals that address the gap in translational science, i.e., turning scientific discoveries into tools and/or treatments for high risk individuals or melanoma patients. Successful proposals will have potential for translational development that could lead to high-impact near-term clinical application in areas of melanoma prevention, diagnosis, staging, and treatment. Development and/or use of novel technologies that have the potential to further such advances in the program's areas of emphasis will be considered.
For the 2011-12 cycle, proposals in the following areas are of particular interest and will receive special consideration: developing combinatorial treatment strategies for patients with unresectable stage III-IV melanoma; exploring biomarkers of treatment response and/or resistance mechanisms to immunotherapy and developing methods to overcome resistance; characterizing molecular pathways driving BRAF wild type melanomas; and defining unique molecular and/or immunological characteristics of acral and amelanotic melanomas in order to identify new therapeutic targets in these patients.

CONTACT: Email questions about this RFP, eligibility, or other questions about MRA or its awards to Laura Brockway-Lunardi, Ph.D., MRA scientific program director, at For more information see The Melanoma Research Alliance.

Register Now!

"Regulations and Ethics in Clinical Research" Course

"Regulations and Ethics in Clinical Research", is a series of 10 weekly sessions as a module in the Institute for Translational Sciences Education Program titled, "Clinical Research: Tools and Techniques". This module will begin Monday, October 10, 2011, 5:15 p.m., Children's Hospital, Room 2.312. The sessions provide an overview of regulations and ethical principles involved in clinical investigation. Get a brochure further describing the sessions here!

IRB ethics preparation, Risk Education, and GME credits are available for selected sessions.

To register, complete and submit the registration form located on the brochure Internet site, or contact the Institute for Translational Sciences – Education Office by email or phone 772-1484. The course fee of $55 covers registration, letter of completion, Risk Education, GME credit, and refreshments. (Those who have already registered for this year's course, "Clinical Research: Tools and Techniques" do not need to register again for this module.)

Click to find out more about the Institute for Translational Sciences!

Virology and Nobel Prizes -
"The Advance of a Scientific Discipline"

Virology and Nobel PrizesErling Norrby, M.D., Ph.D.
Professor of Virology
The Royal Swedish Academy of Sciences
Thursday, 13 October, 12:00 noon
Galveston National Lab (GNL) 1.100

Professor Norrby will present the lecture he gave as the special opening ceremony plenary lecturer at the recent International Congress for Virology in Sapporo.
Professor Norrby was for years a member of the Nobel Committee of the Karolinska Institute, the institution that awards the Nobel Prize in Medicine or Physiology, and was Secretary General of the Royal Swedish Academy of Sciences, the institution that awards Nobel Prizes in Physics, Chemistry, and Economics. He has published a series of papers and then a book on the Nobel Laureates whose discoveries in the field of virology and other life sciences have been seminal in the advance of the sciences. He used his experiences with the Nobel committees, as well as those as a distinguished virologist (especially working with adenoviruses and measles virus) and Professor and Chair of the Department of Virology of the Karolinska Institute, as sources of information and perspective. The proceedings leading to the award of the Nobel Prizes are secret, but the archives are opened 50 years after each award – it is from these archives that much of the unique content of these papers and book, and his seminar, have come. There are many interesting insight into the views and decisions of the committee members who have decided the award of the Nobel Prizes! These decisions, in turn, have had a major influence on the direction of virology research, overall.

Writing Effective Standard Operating Procedures

Thursday, Sept. 29, 2:00-3:00 p.m.
Location: Levin Hall Classroom 3.320
Thursday, Oct. 6, 9:00-10:00 a.m.
Location: Levin Hall Classroom 3.324


Course Overview: Standard Operating Procedures (SOPs) are essential tools for the clinical and research industries. SOPs outline responsibilities, guidelines, implementation procedures, approaches, and ensure consistency within an organization. This course provides a comprehensive introduction to designing, writing, implementing, revising, and updating of SOPs.

Course Objectives: Upon completion of this course, attendees will understand how to effectively and efficiently develop SOPs, identify who should be involved in the creation, training and implementation of SOPs; the length and structure, as well as the pitfalls of SOPs.

Target Audience: This course is valuable for all professionals in basic research, drug discovery, product development, quality assurance, information technology and regulatory affairs. It is also beneficial to senior and middle management executives who want to familiarize themselves with the regulations that mandate procedures and industry standards for writing, implementing and remaining compliant.


Recruitment Registry = Volunteers + Researchers

ResearchMatchRegistry Volunteers: By registering with ResearchMatch, you are registering your willingness to be notified by email about studies that are a potential match based on your anonymous profile and study eligibility. You decide your interest and whether or not to release your contact information to a researcher for direct contact about a study. For more information and to join the registry, go to .

Researchers: By registering to use the recruitment tool, you gain access to anonymous registry data for feasibility searches preparatory to research and may request recruitment search access. More information on using the recruitment tool can be found on the 'ResearchMatch for Researchers' page .

ResearchMatch: This national research recruitment registry is a free and secure web-based service to help connect volunteers with researchers looking for study participants.

ResearchMatch is a collaborative project funded by a Clinical Translational Science Award (CTSA) from the National Institutes of Health to Vanderbilt University in partnership with the UTMB CTSA and other participating CTSA sites. For more information about UTMB's Institute for Translational Sciences, visit

Clinical Research Course 2011-2012

“Clinical Research:  Tools and Techniques”, is a series of 35 weekly sessions offered to faculty, fellows, residents, graduate students and others interested in clinical investigation by the Institute for Translational Sciences – Education Office (Karl E. Anderson, M.D. Course Director).  This course will begin Monday, August 15, 2011, 5:15 p.m., Children’s Hospital, Room 2.312.  The one-hour sessions provide an overview of ethics, methods, and issues in the conduct of research involving human subjects.  Click here for a brochure further describing the sessions.  Risk Education, and GME credits are available for selected sessions.  The course is also offered to students enrolled in the Graduate School of Biomedical Sciences as PHS 6135.

To register, complete and submit the registration form located on the brochure or on the course website. Those who register may choose to attend any or all sessions and may make up missed sessions the next year.  Upon request, participant attendance and self-assessment results may be reported to training program directors. 

For more information contact the Institute for Translational Sciences - Education Office at 772-1484.  The course fee of $55 covers registration, letter of completion, Risk Education and GME credit, and refreshments. 

Asthma Research Study - Volunteers Needed

You may qualify for one of our studies if you are a non-smoker for at least 1 year with a history of physician-diagnosed asthma. You must be between the ages of 18 - 60 and free of other medical problems. Visits are located in the University Hospital Clinics Building (UHC) room 6.214. Participants will be reimbursed for their time. Call Ron at 409-747-1887 for more information.

William J. Calhoun, M.D.
Principal Investigator, Department of Internal Medicine
Director, Multidisciplinary Clinical Trials Office
Director: Coordination Key Resource, CTSA