William J. Calhoun, MD
Sealy and Smith Distinguished Professor
Vice Chair for Research
Department of Internal Medicine
Dr Calhoun has research interests related to the mechanisms of airway inflammation in asthma, and the optimal therapeutic strategies. He has a basic interest in regulation of glucocorticoid receptor function by pro- and anti-inflammatory mediators, conducted with two basic science investigators, Raj Kumar PhD and E Brad Thompson MD. He has a related translational interest in how these mechanisms of steroid resistance may play a role in severe asthma, a clinical disease characterized by steroid resistance. He is also the Principal Investigator for the UTMB-Galveston site of the NIH funded Asthma Clinical Research Network (ACRN). The ACRN is comprised of 8 centers nationally that are charged with designing, conducting, and analyzing clinical trials in asthma that will inform asthma management guidelines, and influence clinical practice. He is the author of one current ACRN trial, BASALT, which aims to identify the optimal management strategy for asthma of mild-moderate severity.